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An Evolutionary Trace method defines functionally important bases and sites common to RNA families
2020
PLoS Computational Biology
Functional non-coding (fnc)RNAs are nucleotide sequences of varied lengths, structures, and mechanisms that ubiquitously influence gene expression and translation, genome stability and dynamics, and human health and disease. Here, to shed light on their functional determinants, we seek to exploit the evolutionary record of variation and divergence read from sequence comparisons. The approach follows the phylogenetic Evolutionary Trace (ET) paradigm, first developed and extensively validated on
doi:10.1371/journal.pcbi.1007583
pmid:32208421
fatcat:c3vaent5zra4dlzn2ftbgtsd4q