STUDY OF THE PROLONGING EFFECT DUE TO THE INTERACTION OF POLYCOMPLEX COMPOSITES WITH MEDICINAL SUBSTANCES
ИЗУЧЕНИЕ ПРОЛОНГИРУЮЩЕГО ЭФФЕКТА ЗА СЧЕТ ВЗАИМОДЕЙСТВИЯ ПОЛИКОМПЛЕКСНОГО КОМПОЗИТА С ЛЕКАРСТВЕННЫМИ ВЕЩЕСТВАМИ

S.Ya Inagamov, K.K. Shadmanov, G.I. Muhamedov
2020 ASJ.  
The nature of the formation of polycomplexes and polycomplex composites was investigated by IR spectroscopy, and the kinetics of the release of drugs from the base were studied by the pharmacokinetic method. Experimental data obtained under "in vitro" conditions showed a prolonging effect in comparison with the initial polymers (Na – CMC) and hydrophobic petrolatum (control), which can be explained by the interaction of drugs with polycomplexes and polycomplex composites. It was found that a
more » ... was found that a high prolonging effect of drugs due to their slow release from the base layers of polycomplex composites.
doi:10.31618/asj.2707-9864.2020.1.39.13 fatcat:oasoo3ewsfcoffu6ka2etcc45y