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Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes
Diabetic retinopathy is one of the leading causes of vision loss and blindness. Extensive pre-clinical and clinical evidence exists for both vascular and neuronal pathology. However, the relationship of these changes in the neurovascular unit and impact on vision remains to be determined. Here, we investigate the role of tight junction protein occludin phosphorylation at S490 in modulating barrier properties and its impact on visual function. Conditional vascular expression of thedoi:10.2337/figshare.14364086.v1 fatcat:6eo4crkehnhr3csnzj7yvu4olq