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An Atlas of Human Kinase Regulation
[article]
2016
bioRxiv
pre-print
The coordinated regulation of protein kinases is a rapid mechanism that integrates diverse cues and swiftly determines appropriate cellular responses. However, our understanding of cellular decision-making has been limited by the small number of simultaneously monitored phospho-regulatory events. Here, we have estimated changes in activity in 215 human kinases in 399 conditions from a compilation of nearly 3 million phosphopeptide quantifications. This atlas identifies commonly regulated
doi:10.1101/067900
fatcat:qk65wcw2dnd4ri6jn5pidjxbhi