Haematological Parameters in Patients with Alcohol Dependence Syndrome

Dr. Chandini, Dr. P. John Mathai
2017 IOSR Journal of Dental and Medical Sciences  
Objective: Alcohol has direct toxic effect on bone marrow and also indirect effect on precursors of all blood cells -red blood cells, platelets and white blood cells. Long term excessive alcohol consumption can interfere with various physiological, biochemical and metabolic processes of the blood cells. The medical consequences of haematological abnormalities can be severe and debilitating. The aim of this study is to evaluate frequency and nature of haematological parameters in inpatients with
more » ... alcohol dependence syndrome and to study the relationship between haematological parameters and clinical variables. Methods: This is an observational, descriptive, cross sectional clinical study conducted on one hundred consecutive patients with ICD10 diagnosis of Alcohol Dependence Syndrome admitted to the deaddiction centre, Department of Psychiatry, Father Muller Medical College Mangalore. Laboratory investigations were done for all inpatients to assess for haematological parameters. Medical diagnosis was based on clinical findings and examination. The data of 100 patients were analyzed using chi-square test, Fischer's Exact Test and Karl Pearson co-relation co-efficient. Results: 100 patients with alcohol dependence syndrome were assessed for haematological parameters of which 36% of individuals have hemoglobin level less than 12 g/dl. 11% of individuals have increased white blood cells and 7% of individual have decreased white blood cells count. 27% of individual have raised Erythrocyte Sedimentation Rate. 60% of individuals with alcohol dependence syndrome have reduced platelet counts. Conclusion: Increasing prevalence of haematological abnormalities is observed in patients with alcohol dependence syndrome. Our findings substantiate the importance for assessment of haematological parameters in patients with alcohol dependence syndrome. The direct and indirect effects of alcohol can result in serious medical complications.
doi:10.9790/0853-1605011116 fatcat:qfqa25chbfevppsypvy5fdpwqm