Defective interferon amplification and impaired host responses against influenza virus in obese mice

Pratibha Gaur, Mathias Riehn, Lisha Zha, Mario Köster, Hansjörg Hauser, Dagmar Wirth
2021 Obesity  
Obesity is a major risk factor that increases morbidity and mortality upon infection. Although type I and type III interferon (IFN)-induced innate immune responses represent the first line of defense against viral infections, their functionality in the context of metabolic disorders remains largely obscure. This study aimed to investigate IFN responses upon respiratory viral infection in obese mice.
doi:10.1002/oby.23196 pmid:34314110 fatcat:gol6t7uxxjdu7latnz4jgfjuzy