Immune reconstitution inflammatory syndrome in HIV and sporotrichosis coinfection: report of two cases and review of the literature

Marcelo Rosandiski Lyra, Maria Letícia Fernandes Oliveira Nascimento, Andréa Gina Varon, Maria Inês Fernandes Pimentel, Liliane de Fátima Antonio, Maurício Naoto Saheki, Sandro Javier Bedoya-Pacheco, Antonio Carlos Francesconi do Valle
2014 Revista da Sociedade Brasileira de Medicina Tropical  
We report 2 cases of patients with immune reconstitution infl ammatory syndrome (IRIS) associated with cutaneous disseminated sporotrichosis and human immunodefi ciency virus (HIV) coinfection. The patients received specifi c treatment for sporotrichosis. However, after 4 and 5 weeks from the beginning of antiretroviral therapy, both patients experienced clinical exacerbation of skin lesions despite increased T CD4+ cells (T cells cluster of differentiation 4 positive) count and decreased viral
more » ... and decreased viral load. Despite this exacerbation, subsequent mycological examination after systemic corticosteroid administration did not reveal fungal growth. Accordingly, they were diagnosed with IRIS. However, the sudden withdrawal of the corticosteroids resulted in the recurrence of IRIS symptoms. No serious adverse effects could be attributed to prednisone. We recommend corticosteroid treatment for mildto-moderate cases of IRIS in sporotrichosis and HIV coinfection with close follow-up.
doi:10.1590/0037-8682-0146-2014 pmid:25626666 fatcat:hcqigt2s2zhkjppfp5ffnprige