The epidemiology of pneumococcal carriage and infections in Malaysia

Cheng-Foh Le, Johanna M Jefferies, Mohd Yasim Mohd Yusof, Shamala Devi Sekaran, Stuart C Clarke
2012 Expert Review of Anti-Infective Therapy  
In Malaysia, various aspects of the epidemiology of pneumococcal carriage and disease remain largely unclear due to the lack of supporting data. Although a number of relevant studies have been documented, their individual discrete findings are not sufficient to inform experts on pneumococcal epidemiology at a national level. Therefore, in this review we aim to bring together and systematically evaluate the key information regarding pneumococcal disease epidemiology in Malaysia and provide a
more » ... a and provide a comprehensive overview of the data. Major aspects discussed include pneumococcal carriage, disease incidence and prevalence, age factors, invasiveness of pneumococci, serotypes, molecular epidemiology and antibiotic susceptibility. Penicillin resistance is increasingly prevalent and studies suggest that the majority of pneumococcal serotypes causing pneumococcal disease in Malaysia are covered by currently available conjugate vaccines. Continued surveillance is needed to provide a better understanding of pneumococcal epidemiology in Malaysia. in the Malaysian pediatric immunization schedule, although licensure for PCV7 was gained in 2006. Malaysian epidemiological data, including serotype-specific disease estimates, are important in order to develop appropriate vaccine policy for the country. However, in common with a number of other southeast Asian countries [5] , information on pneumococcal diseases among the Malaysian population is especially scarce and only a limited number of related studies have been reported throughout the years. The use of data for meaningful comparative analysis is further complicated by the unmatched study designs adopted by individual research groups. The subject population recruited in the respective studies were relatively imbalanced in terms of their geographical and demographical distributions. Data on pneumococcal epidemiology are indeed completely absent for several states. In this review, we aim to provide a comprehensive view on the epidemiology of pneumococcal diseases in Malaysia based on the available literature. Literature review methodology
doi:10.1586/eri.12.54 pmid:22734960 fatcat:pw4u4tl5gjcuxfmxdubgjuhv5q