Digital Twin (DT) is bringing revolution to our lives by a digital representation of the physical system. DT is the creation of the joint usage of various technologies like Cyber-Physical System (CPS), Internet of Things (IoT), Big Data, Edge Computing (EC), Artificial Intelligence (AI), and Machine Learning (ML), etc. DTs are established to optimize a wide range of applications of industry, healthcare, smart cities, smart homes, etc. It is still in its early development stages. This paper

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... the gaps by combining the extensive information on technologies utilized in the creation of DT in industry and healthcare. The paper focuses on studying the characteristics of DT, communication technologies and tools utilized in the creation of DT models, reference models, standards, and the researcher's recent work in smart manufacturing and healthcare. Challenges and open issues that need attention are also discussed. INDEX TERMS Artificial intelligence, big data analytics, communication technologies, digital twin, edge computing, fog, cloud, health care 4.0, industry 4.0, RAMI 4.0.