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Challenges in treatment of patients with acute leukemia and COVID-19: a series of 12 patients

Susanne Ghandili, Susanne Pfefferle, Kevin Roedl, Piet Sonnemann, Panagiotis Karagiannis, Olaf Boenisch, Stefan Kluge, Stefan Schmiedel, Harald Ittrich, Holger Rohde, Marc Lütgehetmann, Katja Weisel (+5 others)
2020 Blood Advances  

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https://web.archive.org/web/20201206111820/https://watermark.silverchair.com/advancesadv2020002543.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA-0wggPpBgkqhkiG9w0BBwagggPaMIID1gIBADCCA88GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMJfn2TEzK5-LGEDRHAgEQgIIDoFW60uQlpOX_8C9G78Ntua_10zIF8lQFw-VdQCn-wZrbJkgGhwmNnQGuA8GRmhs86RgoQ1HYQWIERdoaSflzGUFvbAI2SY6dDIBPtgfOZdOedeYZlVgpNeIl5CFOw0zPz1geMl0mcyMK1J3aLjRu2wswh9jjlM5s1WCP4RdiLBp3z0WnSg33OiQJwLDtKhjxMjmQKaSgWEjyeGlDlXa9xgRHMOALO5XXzNzq-gC2dKsFnINEbWkIotsfzsQil1b1MNC98F8uYw0JoCByRByCgFY8T5L4Ud_ZfN4JbrSySHSUrk4CqVbAOYWyAhwFYb5H--AFwjRI_ZIXwZfpucS2ka3onpG6BLOssZ4I4lcbjjp6nVZSPy92TY4_WrNwu2AH5Zcv3rkH_InzOLlSmAR4OfGlsRdwR64sNk90yhnx-4U5EiKYbnGool3TKWE4LOKqvoebXGrFy1Nbnmc9S2AR0KHxgdq1idTMj0TKQsTtp3SGFbzBYiGf3YkiSC6qSMei9zJoXoRpqK-pxBhD2dX527evNZEbmvxBapds-MHIFXNRHOYUlKpRMSl6wG1kGyIC5xpxXztUJijzIeRwXGfbTOTG3D0-ru2_e_N6krmaj551oEmLlk4x96DJpJRrhRSCmo9hUP3hTDG3wbw_uVceiLcNVho-27JuB7_y_p1CNP9vdOUg0SNEt-23i0EBd8MEDWQSZQVjuVu7wLy7ob401A6OUGSpczwnKxkYXoiMHZGYdffA83z5OQpAzcdoJhV9txPRouBX0auW0qskgpiS3fim3ulno_H6EfZEkw0UhxkcoMFq_XNlILE3_9rzL1WIlKl_nYu1kuaqiHtJriG_wpT9MW425XwznvULsuCVeqrD-ZGNPS8Nz4ZV00a398qlThGrz7EUEfdEasvBry0tO3DKqgiJ7xp67q1qswQIEfjRsFujOg-ffaME7-ZoLTQD9KdVMzbrFWO75HOmQMWBSWJQVdKoYVRS0klUqStdW8wZEIrWCaPv7z6zINeM9QgNqDuSGXEi6c_yJnRPFFcsSMA35cUETmn8tAGfPNCwDkVs1LYjEsSeKgaPsZ2xvqtPs430Q5-pNLRrSSm9hNsbI7QWv8qO3NREp-wFrQ4mnzn0SdHgsUnJlqXCce7DpOk0ZdQ6hLwZzO64vw4WtUaVaC1M9PQ0GBb6Acd8jBcYz3ql-kXdJR56MQcrrSx70CtK5YV0dzSWA1-CfsNdsjScatA

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Key Points Patients with acute leukemia present with a prolonged and severe course of COVID-19, which is paralleled by high rates of viremia. Low-intensive chemotherapy seems to be more feasible in patients with acute myeloid leukemia and concomitant SARS-CoV-2 infection.
doi:10.1182/bloodadvances.2020002543 pmid:33275765 fatcat:d2hyi5jkgzdmjgexkthwtufssu
Citation

Susanne Ghandili, Susanne Pfefferle, Kevin Roedl, Piet Sonnemann, Panagiotis Karagiannis, Olaf Boenisch, Stefan Kluge, Stefan Schmiedel, Harald Ittrich, Holger Rohde, Marc Lütgehetmann, Katja Weisel, Carsten Bokemeyer, Dominic Wichmann, Walter Fiedler, Dominik Jarczak, Franziska Modemann. "Challenges in treatment of patients with acute leukemia and COVID-19: a series of 12 patients." Blood Advances 4.23 (2020) 5936-5941