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AbstractDiabetic nephropathy (DN) is accompanied by characteristic changes in the glomerulus, but little is known about the effect of diabetes on parietal epithelial cells (PECs). In this study, a descriptive analysis of PECs was undertaken in diabetic db/db mice and in diabetic patients. PEC hypertrophy was significantly more prominent in diabetic mice than in nondiabetic mice, and this was evident even at the early stage. Additionally, the number of vacuoles in PECs was markedly increased indoi:10.1038/s41598-021-81027-8 pmid:33452384 pmcid:PMC7810998 fatcat:uqvxgyeqtjc5fpgkcdod35foji