A Novel Anxiety and Affective Spectrum Disorder of Mind and Body—The ALPIM (Anxiety-Laxity-Pain-Immune-Mood) Syndrome: A Preliminary Report

Jeremy Coplan, Deepan Singh, Srinath Gopinath, Sanjay J. Mathew, Antonio Bulbena
2015 The Journal of Neuropsychiatry and Clinical Neurosciences  
The authors describe a spectrum disorder comprising a core anxiety (A) disorder and four domains: joint laxity (L), chronic pain syndromes (P), immune disorders (I), and mood disorders (M)-dubbed the ALPIM syndrome. This study examined 76 consecutive outpatients with an anxiety disorder plus at least one somatic condition from three domains. More than 80% of the patients had panic attacks, fibromyalgia, and major depressive episodes. Associations were found between joint laxity and bipolar III,
more » ... headache with bipolar II, and bipolar II with chronic fatigue syndrome. Significant relationships were demonstrated within and between domains, validating ALPIM as a syndrome.
doi:10.1176/appi.neuropsych.14060132 pmid:25923849 fatcat:5ctgvqevevfore24fy546t7zhm