The present study aimed to investigate the effect of Khella Baladi on the amelioration of kidney dysfunction in hyperoxaluric rats. Thirty-six adult male albino rats were divided into six groups, six rats for each. One of them was kept as a (-ve) control group, while the other five groups were treated with ethylene glycol 0.75% and ammonium chloride 1% for a week via the drinking water to induce hyperoxaluria. Khella Baladi was added to five groups in different quantities (1.5, 3, 4.5, and 6%),

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... respectively. The treatment lasted for 28 days. From the obtained results it was showed that treatment with Khella Baladi in different quantities (1.5, 3, 4.5, and 6%), respectively for 28 days caused a significant (P ≤ 0.05) increase in weight gain%, feed intake, feed efficiency ratio, HDLc, total protein, albumin, globulin, and serum (Na & K), but with significant (P ≤ 0.05) decrease in relative organs weights, liver functions, kidney functions, urine (Na &K), serum glucose, serum bilirubin fractions, TC, TG, LDL, and VLDL. The best treatment was for Khella Baladi 6%. Therefore, it can be concluded that Khella Baladi could minimize the hyperoxaluric effect of (NH4Cl+EG) and potent a diuretic effect.