Modulation of the Transforming Growth Factor β1 by Vitamin E in Early Nephropathy

C. Cojocel, M. Al-Maghrebi, M.S. Thomson, P. Rawoot, R. Raghupathy
2005 Medical Principles and Practice  
content in the renal cortex of diabetic rats recovered towards control values, especially after 10-day treatment. Ma londialdehyde content increased in diabetic rats and was reduced towards control value following 7-and 10day treatments. Treatment of diabetic rats with INS, VE or the combination of INS and VE decreased elevated TGF-␤ 1 in plasma, decreased excretion of TGF-␤ 1 in urine, and decreased renal cortex TGF-␤ 1 mRNA levels. Conclusions: Diabetes-induced overexpression of TGF- ␤ 1 mRNA
more » ... on of TGF- ␤ 1 mRNA was suppressed by VE and INS after 5-, 7-and 10-day treatments. The results obtained with the antioxidant VE suggest that oxidative stress is involved in the development of diabetic nephropathy. Therefore, VE treatment may be effective in early stages of diabetic nephropathy to decrease or prevent pathological complications.
doi:10.1159/000088116 pmid:16220017 fatcat:iyzg72fq2zhytfsrxoacqhclwa