Antioxidant therapy in the elderly with tinnitus

José Fernando Polanski, Alexandra Dezani Soares, Oswaldo Laércio de Mendonça Cruz
2016 Brazilian Journal of Otorhinolaryngology  
Several approaches have been tried for the treatment of tinnitus, from cognitive-behavioral therapies and sound enrichment to medication. In this context, antioxidants, widely used in numerous areas of medicine, appear to represent a promising approach for the control of this symptom, which often is poorly controlled. To evaluate the effects of antioxidant therapy for tinnitus in a group of elderly patients. Prospective, randomized, double-blinded, placebo-controlled clinical trial. The sample
more » ... onsisted of 58 subjects aged 60 years or older, with a complaint of tinnitus associated with sensorineural hearing loss. These individuals completed the Tinnitus Handicap Inventory (THI) questionnaire before and after six months of therapy. The treatment regimens were: Ginkgo biloba dry extract (120mg/day), α-lipoic acid (60mg/day)+vitamin C (600mg/day), papaverine hydrochloride (100mg/day)+vitamin E (400mg/day), and placebo. There was no statistically significant difference between THI by degree (p=0.441) and by score (p=0.848) before and after treatment. There was no benefit from the use of antioxidant agents for tinnitus in this sample.
doi:10.1016/j.bjorl.2015.04.016 pmid:26547700 pmcid:PMC9444615 fatcat:2xz4y32uwrajhepujc5rbuzy3i