Method development and validation for estimation of rufinamide in tablet dosage forms by RP-HPLC

Gandla Kumaraswamy, Repudi Lalitha, K. Vijaypraksh
2016 International Journal of Pharmaceutical Chemistry and Analysis  
A simple, precise, rapid and reproducible stability indicating RP -HPLC method was developed and validated for the determination of Rufinamide in pharmaceutical dosage forms. Chromatography was performed on a C18 (ODS) Acetonitrile: water: Triethylamine buffer pH4.6: Methanol (70:20:10 v/v) was used as mobile phase and flow rate was adjusted to 0.8 ml/ min. The detection was carried out at 292 nm using analytical Tech. UV-Visible detector SpD-10AVP. The obtained calibration curve was linear in
more » ... he concentration range of 10-50ug/ ml. The limit of detection and quantification was found to be 1.056 ug/ml and 3.09 .
doi:10.5958/2394-2797.2016.00015.0 fatcat:77t23d7qerfcde4wocu6c3viey