Hypolipidaemic and anti-atherosclerotic effects of lupin proteins in a rabbit model

Marta Marchesi, Cinzia Parolini, Erika Diani, Elena Rigamonti, Lorena Cornelli, Anna Arnoldi, Cesare R. Sirtori, Giulia Chiesa
2008 British Journal of Nutrition  
The biological activities of a protein isolate from lupin (Lupinus albus) were studied in a rabbit model of atherosclerosis. Focal plaque development was induced at both common carotid arteries by perivascular injury. After surgery, animals were fed three different diets for 90 d, all with 1 % cholesterol, 15 % SFA and 20 % protein; the protein source was casein (CAS), lupin proteins (LUP) or 50 % CAS þ 50 % LUP (CAS þ LUP). Lower cholesterolaemia was detected in the LUP v. the CAS group at 60
more » ... nd 90 d of treatment (2 40·3 and 233·5 %, respectively; P, 0·05). Cryosection analyses of the carotids indicated a significant reduction in focal lesion progression in the LUP v. the CAS group (2 37·4 %; P, 0·05). In summary, in a rabbit model of atherosclerosis, a protein isolate from L. albus reduced cholesterolaemia and exerted a remarkable protective activity against atherosclerosis progression.
doi:10.1017/s000711450894215x pmid:18315889 fatcat:x5kv4k5gojduxhqyv77yrpbxfm