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P014 IgLON5 Disease – A Review of 2 Cases and Sleep Manifestations
Background IgLON5 disease is a novel autoimmune tauopathy with diverse sleep and neurologic manifestations. Sleep disorder is a common initial presentation and may precede disease progression. Neurological symptoms frequently overlap with extrapyramidal syndromes, motor neuron disease and dementia. Diagnosis is confirmed by anti-IgLON5 IgG in CSF and/or serum. Strong HLA-DRB1*1001 and HLA-DQB1*0501 association supports autoimmune mechanism. Video-PSG is recommended to identify treatabledoi:10.1093/sleepadvances/zpac029.087 fatcat:jephprfbg5dh5ieabxunlfjlz4