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Searching for protein structure-function relationships using three-dimensional (3D) structural coordinates represents a fundamental approach for determining the function of proteins with unknown functions. Since protein structure databases are rapidly growing in size, the development of a fast search method to find similar protein substructures by comparison of protein 3D structures is essential. In this article, we present a novel protein 3D structure search method to find all substructuresdoi:10.1089/cmb.2011.0230 pmid:22509779 fatcat:hoc2qz4yafhgxftfbxlctla2w4