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Kinetics of self-assembly via facilitated diffusion: Formation of the transcription complex
2015
Physical Review E
We present an analytically solvable model for self-assembly of a molecular complex on a filament. The process is driven by a seed molecule that undergoes facilitated diffusion, which is a search strategy that combines diffusion in three-dimensions and one-dimension. Our study is motivated by single molecule level observations revealing the dynamics of transcription factors that bind to the DNA at early stages of transcription. We calculate the probability that a complex made up of a given
doi:10.1103/physreve.92.042716
pmid:26565281
fatcat:76g3orsinvfwjl67zvdto7jbdq