Exploration and Suppression of Cardiac Amyloidosis Induced by Huntington's Disease-Causing Amyloid in the Drosophila Heart Model

Girish C. Melkani, Rolf Bodmer, Karen Ocorr, Sanford I. Bernstein
2012 Biophysical Journal  
capable of detecting mechanical separation of the muscle layers, which was found to occur more frequently in w1118 than yw (0.415 0.04 vs. 0.00 5 0.02 mm separation, respectively, 1 week flies). Detection of mechanical separation between muscle layers via nanoindentation was modeled and verified in a microfabricated polydimethylsiloxane system. This first in situ mechanical analysis of a living myocardium revealed differences in cardiac mechanics due to age and suggest that aspects of the
more » ... ical properties of the aging phenotype differ between Drosophila strains. We investigation on other laboratory Drosophila wildtype strains to assess the impact of diverse genetic backgrounds or mutations on age-related myocardial stiffening and cardiomyopathy.
doi:10.1016/j.bpj.2011.11.1923 fatcat:wcm46rudrjfkfeu7kysuuwib5q