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Production of GM-CSF Mediated by Cysteine Protease of Der f in Canine Keratinocytes
2012
Journal of Veterinary Medical Science
House dust mite (HDM) allergens are the most common allergens for induction of IgE-mediated hypersensitivity. Recently, epicutaneous sensitization with HDM allergens has been emphasized in the development of atopic dermatitis (AD) by producing various soluble factors in keratinocytes. Among the soluble factors, GM-CSF is a key molecule that activates Langerhans cells, antigen-presenting cells in the epidermis. In the present study, we investigated the effects of Dermatophagoides farinae (Der f)
doi:10.1292/jvms.11-0522
pmid:22446400
fatcat:f3r5dswfafbs7n2pmbtbhppyke