Review and classification of variability analysis techniques with clinical applications

Andrea Bravi, André Longtin, Andrew JE Seely
2011 BioMedical Engineering OnLine  
Analysis of patterns of variation of time-series, termed variability analysis, represents a rapidly evolving discipline with increasing applications in different fields of science. In medicine and in particular critical care, efforts have focussed on evaluating the clinical utility of variability. However, the growth and complexity of techniques applicable to this field have made interpretation and understanding of variability more challenging. Our objective is to provide an updated review of
more » ... riability analysis techniques suitable for clinical applications. We review more than 70 variability techniques, providing for each technique a brief description of the underlying theory and assumptions, together with a summary of clinical applications. We propose a revised classification for the domains of variability techniques, which include statistical, geometric, energetic, informational, and invariant. We discuss the process of calculation, often necessitating a mathematical transform of the time-series. Our aims are to summarize a broad literature, promote a shared vocabulary that would improve the exchange of ideas, and the analyses of the results between different studies. We conclude with challenges for the evolving science of variability analysis. Bravi et al. BioMedical Engineering OnLine 2011, 10:90
doi:10.1186/1475-925x-10-90 pmid:21985357 pmcid:PMC3224455 fatcat:f3xofnuiubgedlcqefalfsj5c4