Oxygen Saturation Imaging Using LED-Based Photoacoustic System

Rianne Bulsink, Mithun Kuniyil Ajith Singh, Marvin Xavierselvan, Srivalleesha Mallidi, Wiendelt Steenbergen, Kalloor Joseph Francis
2021 Sensors  
Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this technology, there is a need to improve its accuracy and validate it against ground truth methods. We propose a fluence compensated oxygen saturation imaging method, utilizing structural information from the ultrasound image, and prior knowledge of the optical
more » ... f the optical properties of the tissue with a Monte-Carlo based light propagation model for the dual-wavelength LED array configuration. We then validate the proposed method with oximeter measurements in tissue-mimicking phantoms. Further, we demonstrate in vivo imaging on small animal and a human subject. We conclude that the proposed oxygen saturation imaging can be used to image tissue at a depth of 6–8 mm in both preclinical and clinical applications.
doi:10.3390/s21010283 pmid:33406653 fatcat:rfxym2dgy5gvdirsew267aqd4q