Surgical management of an extra gastrointestinal tumor (EGIST) of unspecified etiology, with voluminous liver and peritoneal metastases – case presentation
Revista Medicală Română
Since gastrointestinal stromal tumors (GIST) were defined as a nosological entity only at the beginning of the millennium, their exact diagnosis having a relatively short history, both in Romania and internationally, studies are still being carried out aimed at establishing the incidence or studying the course of the disease. This is all the more difficult because GISTs present themselves clinically in a multitude of forms, which can develop from the esophagus to the anus and sometimes
... sometimes extragastrointestinal (EGIST), and from an oncological point of view range from a small harmless tumor node to a metastatic sarcoma with vital potential. Gastrointestinal stromal tumors (GIST), soon after it was proven that the main mechanism involved in their ethiopaty is a KIT or PDFRGA mutation, became the first targets of tyrosine-kinase inhibitor (TKI) therapy, being the first solid tumors treated with Imatinib. As a rare pathology, studies carried out in the country were carried out in relatively small batches and generally analyzed the experience of a single medical center. In this context, the case of our patient with EGIST with hepatic localization but unspecified etiology, with a favorable response to combined surgical and chemotherapy treatment with Imatinib becomes even more relevant to get the attention of surgeons facing this pathology.