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Association between the Methylation of CpG Islands in JAK-STAT Pathway-Related Genes and Colorectal Cancer
Background: The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is involved in a series of biological processes. Aberrant promoter methylation of CpG islands plays an important role in carcinogenesis. However, the association between the DNA methylation of JAK-STAT pathway-related genes in peripheral blood leukocytes and colorectal cancer (CRC) susceptibility remains unclear. Methods: We conducted a case-control study of 403 patients with CRC and 419 cancer freedoi:10.21203/rs.3.rs-49979/v1 fatcat:jus3op2kwjaqph3snxrrtg5qwi