A small percentage of pregnant women experience a severe form of nausea and vomiting called Hyperemesis gravidarum. To compare the rate of H. pylori infection between an Iranian samples of pregnant women who were suffering from hyperemesis gravidarum (HG) in their first trimester and control pregnant women without HG. Methods: In this cross-sectional study 30 pregnant women who suffered from HG and 30 controls were enrolled. H. pylori specific serum IgG was measured using ELISA method. IgG

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... s of more than 10, less than 10 and between 5 and 10 U/mL were considered as seropositive, seronegative and suspicious for H. pylori infection, respectively. Results: No significant difference was seen between the two groups regarding age, gestational age and gravidity. Twenty-four patients (92.3%) in HG group had H. pylori infection, while this rate was only 7.7% (two patients) in control group (P < 0.001). No correlation was detected between IgG titers and either maternal age (t=2.4, P = 0.12) or parity (x =0.2, P = 0.6). Conclusion: There was 2 significantly higher rate of H. pylori infection in HG pregnant women in their first trimester in comparison to controls.