Th e aim of the study was to evaluate the possible association between Apo E polymorphisms and age at seizure onset in patients with non-lesional temporal lobe epilepsy. Eighty patients with non-lesional temporal lobe epilepsy with or without bilateral tonic-clonic propagation were analyzed. Age at seizure onset was defi ned as age at the fi rst unequivocal seizure (excluding febrile convulsions). ApoE alleles were determined by a procedure where genome DNA was amplifi ed by chain reaction

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... with polymerase, using the LightCycler kit (Roche) for ApoE mutations on codons 112 and 158. Th ere was a statistically signifi cant diff erence between the groups of patients with ApoE ε2/3 and ε3/4 genotypes (p=0.03), but not between patients with ApoE ε2/3 and ε3/3, and those with ApoE ε3/4 and ε3/3. In conclusion, the results of our study suggested positive association of a specifi c ApoE genotype and onset of non-lesional temporal lobe epilepsy.