Background: this study aimed to understand the effective of exclusive enteral nutrition on clinical remission and mucosal healing with pediatric Crohn's disease (CD)in a real-world setting in southern China. Methods: In this prospective disease registry, children (aged between 2 and 18years)with newly diagnosed luminal CD were recruited from December 2018 to December 2020. Patients were examined at baseline and at weeks3 and 8 of EEN induction. Logistic regression analysis is used to assess the

more »

... influencing factors of EEN. Results: The clinical remission and mucosal healing rate of children is 76.5%、35% separately after 8 week induction. The remission rate of mild CD is higher than that of moderate-severe CD, but it is not statistically significant(p=0.01). Disease location、age、the response rate at week 3 all do not predict the effectiveness of EEN treatment.Conclusions: EEN can effectively promote clinical remission and mucosal healing of southern China pediatric Crohn's disease in short time and is also recommend as the first-line therapy for children with severe luminal CD