Organophosphorus compounds play an important role in the medicinal-or agricultural industry, and in the human body as well. Over the last years, heterocyclic phosphonates have received an intensively growing interest due to their potential biological activity. An efficient tool for the preparation of such derivatives is their synthesis via multicomponent reactions. These transformations possess several criteria of an "ideal synthesis", such as the high atom economy, the fast and simple

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... hment, the energy efficiency and the environmentally friendliness. A number of heterocyclic phosphonates were prepared by us utilizing multicomponent syntheses. In this proceeding, the synthesis of the diethyl (2-amino-3-cyano-4H-chromen-4-yl)phosphonate by the condensation of salicylaldehyde, malononitrile and diethyl phosphite is briefly introduced. The reaction was optimized in respect of the catalyst type, the catalyst amount, the reaction time, and the temperature.