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Effects of Oleanane-Type Triterpenoids from Fabaceous Plants on the Expression of ICAM-1
Biological and Pharmaceutical Bulletin
We examined the inhibitory effects of oleanane-type triterpenoids from fabaceous plants on the TNF-a a-induced expression of cell adhesion molecules on THP-1 human monocytic leukemia cells and compared them with a glucocorticoid dexamethasone. In a cell-based ELISA, abrisapogenol E, soyasapogenols B and C, soyasapogenol B, kuzusapogenol B-methyl ester, and oleanolic acid significantly inhibited intercellular adhesion molecule (ICAM-1) expression. Moreover, these triterpenoids showed the samedoi:10.1248/bpb.25.1105 pmid:12186419 fatcat:dshevi5xgvhqbiptj2vx652otm