Effects of Oleanane-Type Triterpenoids from Fabaceous Plants on the Expression of ICAM-1

Kyung-Seop Ahn, Jung-Hee Kim, Sei-Ryang Oh, Byung-Sun Min, Junei Kinjo, Hyeong-Kyu Lee
2002 Biological and Pharmaceutical Bulletin  
We examined the inhibitory effects of oleanane-type triterpenoids from fabaceous plants on the TNF-a a-induced expression of cell adhesion molecules on THP-1 human monocytic leukemia cells and compared them with a glucocorticoid dexamethasone. In a cell-based ELISA, abrisapogenol E, soyasapogenols B and C, soyasapogenol B, kuzusapogenol B-methyl ester, and oleanolic acid significantly inhibited intercellular adhesion molecule (ICAM-1) expression. Moreover, these triterpenoids showed the same
more » ... ivity as dexamethasone. On the other hand, the absence of hydroxyl group at C-24 position of sapogenin rather to increase ICAM-1 expression compared with the untreated control. We concluded that the activity of oleanane saponins and sapogenins against ICAM-1 expression are dependent upon the position of the hydroxyl group, and in particular upon the status of the C-21 and C-24 positions and of the glycosyl group at C-3 position.
doi:10.1248/bpb.25.1105 pmid:12186419 fatcat:dshevi5xgvhqbiptj2vx652otm