This work discusses the relationship of the biological aging between mole-rats and rats through a unified approach from the perspective of thermodynamics. Taking calorimetric data from some published studies of the metabolism on mole-rats and rats, it is calculated the entropy production rate. It is observed that the entropy production rate in rats decays with chronological age, and develops a kind of first order phase transition. However, the mole-rats, showed that entropy production rate did

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... ot change significantly with age and exhibits a slightly higher value as an average compared to the rats analyzed. This result can be interpreted in terms of a mole-rats exhibit a more robustness, i.e. greater plasticity than rats. Furthermore, it is shown that the entropy production rate could be consider as a physical marker of biological age and a predictor of Lifespan.