Effects of Five Per Cent Dextrose-Water Infusions in Normal and Hypertensive Man

1968 Circulation  
During infusions of 5% dextrose in water urinary sodium excretion and the renal tubular rejection of filtered sodium (E/F Na %) were significantly higher in hypertensive than in normotensive subjects. Increased E/F Na % did not result from alterations in plasma sodium, in filtered sodium, or from an osmotic diuresis. Fractional sodium reabsorption in proximal (isosmotic) portions of the nephron was diminished in the hypertensive patients. Free water forrnation (CH20) rose with in-
doi:10.1161/01.cir.37.5.832 pmid:4869293 fatcat:k3k6gixg2zaa5nzqaouox7xil4