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Accumbens D2-MSN hyperactivity drives behavioral supersensitivity
Antipsychotic-induced behavioral supersensitivity is a problematic consequence of long-term treatment with antipsychotic drugs and is characterized by emergence of refractory symptoms and dyskinesias. The underlying mechanisms are unknown, and no rational approaches exist to prevent or reverse antipsychotic-induced supersensitivity. Here we describe major adaptations impacting populations of striatal medium spiny neurons (MSNs) during the development of behavioral supersensitivity and reveal adoi:10.1101/2020.11.12.380667 fatcat:vczo3ujzwvcp3kosvmbm5hzt6e