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A Density-Dependent Switch Drives Stochastic Clustering and Polarization of Signaling Molecules
2011
PLoS Computational Biology
Positive feedback plays a key role in the ability of signaling molecules to form highly localized clusters in the membrane or cytosol of cells. Such clustering can occur in the absence of localizing mechanisms such as pre-existing spatial cues, diffusional barriers, or molecular cross-linking. What prevents positive feedback from amplifying inevitable biological noise when an un-clustered "off" state is desired? And, what limits the spread of clusters when an "on" state is desired? Here, we
doi:10.1371/journal.pcbi.1002271
pmid:22102805
pmcid:PMC3213192
fatcat:z65plogmsnforbi7fcm3azgj4u