Induction signals for vancomycin resistance encoded by the vanA gene cluster in Enterococcus faecium

M H Lai, D R Kirsch
1996 Antimicrobial Agents and Chemotherapy  
The induction of vancomycin resistance in enterococci containing the vanA gene cluster is thought to be controlled by a two-component sensor-response regulator system encoded by vanR and vanS. Eight inducing compounds were identified by screening a panel of more than 6,800 antibiotics and synthetic compounds including the three tested glycopeptides (vancomycin, avoparcin, and ristocetin), two other cell wall biosynthesis inhibitors (moenomycin and bacitracin), two cyclic peptide antibiotics
more » ... ibiotic AO341 beta and polymyxin B), and a macrocyclic lactone antibiotic (moxidectin). Induction activity by structurally unrelated antibiotics suggests that the induction signal is not a structural feature of vancomycin.
doi:10.1128/aac.40.7.1645 fatcat:tiro66e2yjatvdlfup47gyzkwq