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Insulin is administered for glycemic control in type 2 diabetic patients with secondary failure to oral antidiabetic drugs. Achieving good glycemic control requires a long time with relatively high insulin dose. Objective: The aim of this study was to compare the effect of treatment with insulin alone versus insulin plus sulfonylurea in type 2 diabetic patients. Methods: In this randomized clinical trial, 45 patients with secondary failure to oral antidiabetic drugs who referred to Bou-Alifatcat:agkfrhdwhrgmxcdtq5gkbl3hae