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Identification of the Interface between cGMP-dependent Protein Kinase Iβ and Its Interaction Partners TFII-I and IRAG Reveals a Common Interaction Motif
Journal of Biological Chemistry
Protein-protein interactions have emerged as an important mechanism providing for specificity in cellular signal transduction. Two splice variants of type I cGMP-dependent protein kinase (PKG I␣ and I␤) differ only in their N-terminal ϳ100 amino acids, which mediate binding to different target proteins. PKG I␤, but not I␣, binds to the general transcriptional regulator TFII-I and the inositol 1,4,5-trisphosphate receptor-associated PKG substrate IRAG. Using a combination of site-directeddoi:10.1074/jbc.m507021200 pmid:16166082 fatcat:qdquxphfzre6hhonr62nu6aeb4