null integrative workflow to study large-scale biochemical networks

Faiz Muhammad Khan
2019
I propose an integrative workflow to study large-scale biochemical networks by combining omics data, network structure and dynamical analysis to unravel disease mechanisms. Using the workflow, I identified core regulatory networks from the E2F1 network underlying EMT in bladder and breast cancer and detected disease signatures and drug targets, which were experimentally validated. Further, I developed a hybrid modeling framework that combines ODE- with logical-models to analyze the dynamics of
more » ... arge-scale non-linear systems. This thesis is a contribution to interdisciplinary cancer research.
doi:10.18453/rosdok_id00002554 fatcat:7qh6x3qrrzg77omjs767bpwhri