Purpose Physical activity (PA) has been evaluated for reducing side effects of cancer treatment and improving quality of life. Understanding the factors that affect participation in PA is essential to improve strategies for health promotion. We evaluated the determinants of PA among prostate cancer patients. Methods Ninety patients were divided into 'inactive or minimally active' or 'health enhancing physical activity' groups, based on their PA levels measured using the International Physical

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... tivity Questionnaire (IPAQ). IPAQ score was used as the dependent variable. Clinical characteristics, including demographics, difficulties in urination or defecation, socioeconomic status, physical status and functions were used as the independent variables. Univariate and multivariate logistic regression analyses were performed. Results Univariate logistic regression analyses identified that urination and defecation difficulties were associated with lower PA. Multivariate logistic regression analyses revealed that urinary difficulties were associated with lower PA. Conclusion Knowledge of the factors that influence PA will allow physicians to identify patients who are expected to have less PA and intervene early. Urinary difficulties had a statistically significant association with lower PA, representing a barrier to PA. Early intervention is needed to overcome urinary difficulties considering the importance of PA in achieving optimal health outcomes.