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Decline in telomerase activity as a measure of tumor cell killing by antineoplastic agents in vitro
1997
Clinical Cancer Research
Telomerase activity is frequently associated with the malignant phenotype, and it can be considered an almost ubiquitous tumor marker. In this study, we evaluated telomerase activity in telomerase-positive human tumor cell lines exposed in vitro to antineoplastic agents. The results show that drug-induced cell killing of tumor cells is associated with a decline in detectable telomerase activity. The decrease of telomerase activity levels paralleled cell growth impairment evaluated by cell count
pmid:9815723
fatcat:7rn4y4dio5bedoieumxfbhcngi