Education (CHRE), an independent healthcare company, which works on projects on smoking cessation and cancer prevention globally. CHRE has received grants from Foundation for a Smoke-free World, Inc for some of its smoking cessation projects. Previously, SP was an employee of Nicoventures, a wholly owned subsidiary of British American Tobacco, till February 2019. SP does not have any financial interest in the nicotine pouches category. Dr Fagerström has received consulting fees from many

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... es that develop or market pharmaceutical and behavioural treatments for smoking cessation. In year 2000 he started a company Niconovum that developed the first non-tobacco nicotine pouch that was licensed as an NRT. He currently receives consulting fees from Swedish Match and has received fees in the past from tobacco companies to assist their development of less-risky tobacco products. Abstract Nicotine extracted from tobacco and purified from other constituents can be delivered in the form of nicotine replacement products for helping people move away from tobacco dependence. Nicotine pouches to be put under the upper lip are one such new category of products that are being rapidly developed and marketed as consumer goods with little research or regulatory oversight. We review the available data on these products and their harm reduction potential for reducing the disease and death burden from tobacco globally. Finally, we have identified research gaps in assessing their harm and benefit potential, and possible regulatory approaches to ensure that these products do not lead to unintended consequences. Tobacco related harms and Harm Reduction Qeios, CC-BY 4.0 · Article,