THE ACTION OF CERTAIN DRUGS ON BRAIN CIRCULATION IN MAN
Archives of Neurology And Psychiatry
The pharmacologic response of the brain vessels in man is a question presenting more than ordinary difficulty to experimental study, particularly under normal, nonoperative conditions. The only work of any significance in the latter connection is that of Shepard,1 and even here the matter of specific drug effect is but incidentally dealt with \p=m-\only one group, that of the nitrites, having been definitely reported. It was deemed distinctly fortunate, therefore, .when the presentation of a
... resentation of a suitable subject rendered further investigation possible. REPORT OF CASE The subject R. K., aged 40, a male patient at the State Psychopathic Hospital, had undergone double subtemporal decompression for the relief of increased intracranial pressure, presumably of tumor origin. The first decompression had been performed nine months, and the second, eight months prior to the initiation of this study, the patient, having by that time, fully recovered from all operative reaction. There developed residually, however, at the decompression sites, two large, pulsating cerebral hernias, each about the size and shape of a lemon. Mentally, the patient, though showing a certajn deteriora¬ tion, was fully capable of satisfactory cooperation. METHOD oe PROCEDURE Specifically, the procedure was as follows : The subject was required to lie at full length on his left side, with his face flat to the pillow, thus furnishing a level and stable support for the presenting right hernial mass, and extreme care was taken to maintain this position throughout each observation period. The site of the pre¬ senting mass was shaved and encircled by a bed of putty into which was set, so as to enclose the mass completely, an ordinary glass funnel of suitable size.