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Adaptive designs are playing an increasingly important role in the planning of clinical trials. While there exists various research on the optimal determination of a two-stage design, non-optimal versions still are frequently applied in clinical research. In this article, we strive to motivate the application of optimal adaptive designs and give guidance on how to determine them. It is demonstrated that optimizing a trial design with respect to particular objective criteria can have adoi:10.1002/sim.8953 pmid:33738842 fatcat:wfnoobc2xnhnvd4uh4qum4oggm