A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf
.
Evolving Concept of Activity Cliffs
2019
ACS Omega
Activity cliffs (ACs) are generally defined as pairs or groups of structurally similar compounds that are active against the same target but have large differences in potency. Accordingly, ACs capture chemical modifications that strongly influence biological activity. Therefore, they are of particular interest in structure-activity relationship (SAR) analysis and compound optimization. The AC concept is much more complex than it may appear at a first glance, especially if one aims to represent
doi:10.1021/acsomega.9b02221
pmid:31528788
pmcid:PMC6740043
fatcat:7lbdx34al5hwrfitfqdsr22nxm