Fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases: a pediatric case report

Shuwen Zhong, Jingqing Zeng, Zhaohui Deng, Lirong Jiang, Bin Zhang, Kaihua Yang, Wenyu Wang, Tianao Zhang
<span title="2019-08-28">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/z4gdwga7tncvdfn2z2eb7civka" style="color: black;">Italian Journal of Pediatrics</a> </i> &nbsp;
Immunocompromised (IC) patients have an increased risk of refractory diarrhea. Fecal microbiota transplantation (FMT) is a safe and effective therapy for infection-related diarrhea which are mainly mediated by the loss of the microbial colonization, although there is concern that IC patients may be at higher risk of infectious complications related to FMT. And reports of FMT in IC children are limited. We describe two cases of FMT in IC children with refractory diarrhea. One IC child had
more &raquo; ... ocrinopathy, enteropathy, X-linked syndrome and the other child had graft-versus-host disease. Both of the children had a long course of diarrhea and no response to traditional treatment. FMT was performed on both patients via nasojejunal tubes under guidance of gastroduodenoscopy. After FMT, the patients achieved remission of symptoms and neither of them had related infectious complications. Microbiota analysis showed that FMT resulted in reconstruction of a diverse microbiota. Use of FMT is safe and effective in treatment of refractory diarrhea in IC children with a damaged microbiota.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13052-019-0708-9">doi:10.1186/s13052-019-0708-9</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31462301">pmid:31462301</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6714385/">pmcid:PMC6714385</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/snksyvm25vgknfisyhhsv3xfl4">fatcat:snksyvm25vgknfisyhhsv3xfl4</a> </span>
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