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Upregulation of Nitric Oxide Synthase Activity by All-trans Retinoic Acid and 13-cis Retinoic Acid in Human Malignant Keratinocytes
2019
Biomedical Science Letters
Effect of retinoids, i.e., all-trans retinoic acid and 13-cis retinoic acid, on the activity of nitric oxide synthase (NOS) was evaluated in human malignant keratinocytes to examine the possible correlation of retinoids with NOS activities. All-trans retinoic acid and 13-cis retinoic acid did not alter the nitric oxide (NO) production. However, in the presence of lipopolysaccharide (LPS, 1 μg/mL), they significantly increased NO release in a dose-dependent manner until 48 h at concentrations of
doi:10.15616/bsl.2019.25.2.196
fatcat:my22chnj2fa6zepmlofkzfhkdq