Hemophilia is a coagulation disorder arising from a genetic defect of the X chromosome; the defect can either be inherited or result from spontaneous gene mutation. In each type of hemophilia (A, B, C, and willebrands disease), a critical coagulation protein is missing, causing children to bleed for long periods of time before clotting occurs. Aim: this study was a quasiexperimental aimed to evaluate the outcomes of the instructional module on the studied sample. Setting: the study was carried

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... ut at hematology departments at children's hospitals affiliated to Ain Shams University Hospital (Al Demerdash) Cairo University Hospital (Abo Elreesh) and Benha children's Hospital affiliated to ministry of health. The Sampling: A convenient sample involved Fifty nurses from the previously mentioned settings. Tools of data collection: involved a structure questionnaire to assess nurses' knowledge and observational checklists to assess performance regarding care of children with hemophilia and instructional module about hemophilia. Results: Slightly less than half (46.0% &48%) of the studied nurses their ages were 30 years and more, had nursing diploma from technical institute of nursing respectively, less than two thirds of the nurses (62%) had experience ≥ 6years, Post implementation of the instructional module most of the studied nurses had satisfactory level of knowledge and competent practice in comparison to pre implementation of the instructional module. Conclusion: The designed instructional module led to significant improvement of knowledge and performance of the studied nurses towards care of hemophilic children. Recommendations: continuous refreshing training should be provided for all of nurses working in hematological departments and caring of children with hemophilia. A manual guided booklet about hemophilia should be available to all nurses working in hematological departments.