Objectives: Individuals with joint hypermobility (JH) constitute a sensitive group with regard to musculoskeletal problems. This study aimed to investigate whether females with generalized joint hypermobility (GJH) are at risk of hypovitaminosis D compared with non-GJH female participants and whether there is a relationship between vitamin D levels, Beighton score and musculoskeletal complaints. Methods: In this cross-sectional, descriptive and case-control study, 76 female participants aged

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... 25 years were included. The Beighton score with a cut-off of 4/9 was applied for defining GJH. In addition, serum biochemical (the enzymatic colorimetric method) and hormonal (the electrochemiluminescence method) parameters were evaluated. Results: The mean serum 25-hydroxyvitamin D (25[OH]D) levels of GJH (n = 38) and non-GJH (n = 38) groups were 15.70 ± 7.96 ng/mL and 16.80 ± 5.45 ng/mL, respectively. There was no statistically significant difference between the groups in terms of biochemical and hormonal parameters. We found vitamin D deficiency in 89.5% of participants with GJH, and 84.2% of controls. There was no correlation between vitamin D, Brighton criteria, and musculoskeletal complaints. Conclusion: The female participants with GJH showed similar frequency of musculoskeletal complaints and similar low level of 25(OH)D in relation to controls. The European Research Journal 2019;5(4):576-581 oint hypermobility or laxity is having a range of motion beyond the limits of normal joint. It can affect one or more joints. Beighton scoring (BS), where in nine joints are evaluated, is used to define JH and BS 4-6/9 is reported as generalized joint hypermobility (GJH) [1, 2] . Hypermobility brings with it many problems as musculoskeletal or systemic manifestations. Musculoskeletal manifestations are trau-mas, degenerative joint and bone diseases, disturbed proprioception, muscle weakness and musculoskeletal traits. Systemic manifestations are cardiovascular involvements, skin, mucosae, fascia involvement, and nervous system involvement [2]. These manifestations were included easily under the umbrella named hypermobility syndrome or hypermobile Ehlers-Danlos syndrome (hEDS) with Brighton criteria until the 2017 J