SP326FEBUXOSTAT IMPROVES GFR AND BP IN NON-DIABETIC ADULTS WITH CKD 2-3: 4 YEARS FOLLOW-UP

Dmytro D Ivanov, Mariia D Ivanova
2015 Nephrology, Dialysis and Transplantation  
Introduction and Aims: Asymptomatic elevated uric acid levels are frequent in CKD. Lowering uric acid with allopurinol improves GFR, BP and might decrease cardiovascular events in CKD patients. The aim of the study was to investigate the influence of febuxostat on GFR and BP in non-diabetic patients with CKD 2-3 with mild hypertension and no history of gout. Methods: 56 patients with asymptomatic hyperuricemia and CKD 2-3 (GFR 54±3 ml/ min) were enrolled in 14-month randomized prospective
more » ... d prospective open-label study in parallel
doi:10.1093/ndt/gfv191.46 fatcat:qq5cdsmc4rh5dahtq3wgkk2u6y